I have now been on estradiol injections for an entire dosage cycle (14 days) and it seems to be going pretty well. The injections themselves are fairly easy and are much more convenient than taking a pill every 6 hours. And even better, my fear of negative effects on my mental health during the last 2-4 days of the cycle was unwarranted. I have not experienced any kind of unevenness in mood either in the days following the injection or the days before my next one. I am very happy with how the switch to injections has gone and relieved by the lack of emotional effects. If my current dosage can finally get my levels in a proper place (and I should know by end of April), I may have found the ideal dosage and schedule for me.